The SPOG Research Council is the leading body of the association.

The Swiss Paediatric Oncology Group (SPOG) Research Council consists of: 

- 2 representatives from each university or equivalent paediatric oncology centre in Basel, Bern, Geneva, Lausanne, St.Gallen and Zurich
- 1 representative from each children’s hospital in Aarau, Lucerne and Bellinzona
-  1 representative from the Swiss Childhood Cancer Registry
- 1 representative from each of the medical societies for paediatric surgery, radiology and pathology
- 1 representative from data managers.